A man, 22, was flown to Orange hospital in a serious condition after he crashed into a parked car containing two people in Cargo on Saturday night.
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A NSW Ambulance spokesman said the man suffered head and neck injuries.
Police said the man, an Irish national from Randwick, crashed into a street sign and telegraph pole before hitting the other car.
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Central West Police District Inspector Shane Jessep said a man, 53, and a woman, 47, from Orange were taken to Orange Hospital by ambulance after suffering minor injuries.
He said police were awaiting the result of blood tests from the driver of the other car.
Inspector Jessep said the crash occurred outside the Cargo Inn hotel in Belmore Street about 10.25pm.
The ambulance spokesman said three ambulances and the helicopter were among the emergency services called to the accident scene.
He said they received the call to attend the accident at about 10.30pm.
Investigations into the accident are continuing.