About 50 jobs will need filling at the $35 million Western Cancer Centre Dubbo (WCCD), which is expected to be completed in the middle of this year.
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Doctors, nurses, allied health professionals, support services and administration staff are among the people needed to run the WCCD, currently under construction on the grounds of Dubbo Hospital.
Recruitment is underway and currently focused on "a number of key positions within radiation oncology", a new service in Dubbo and the western region.
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"We are encouraging anyone from within the Dubbo Hospital, across the broader Western NSW Local Health District (WNSWLHD) and from further afield to apply for the positions," its spokesman said.
"It is planned that all leadership positions will be in place prior to the WCCD opening to assist with commissioning the services."
"All existing oncology staff" are reported to be looking forward to moving to the WCCD.
They will be accompanied by volunteers, the Pink Ladies, who have been working at the Alan Coates Cancer Centre for many years.
The WNSWLHD spokesman said the Pink Ladies would continue to provide food and beverages for cancer patients.
"Importantly, they also just provide a friendly face for people when they arrive at the department and will often have a chat with patients and/or carers whilst they are there," he said.
The federal government is spending $25 million and the state government $10 million on the WCCD.
It will have the only PET CT scanner in Western NSW, a bunker for radiation therapy, 16 chemotherapy treatment spaces and a designated space for a second bunker.