The mural was started last week.

When completed, the artwork will be 500 metres-squared, making it the largest mural in the city.

It's being led by Dubbo's Jack Randell, in collaboration with numerous artists from across the region.

"The brief for the Macquarie Home Stay mural was to create a design that is emblematic of the whole region, from the mountains to the plains," he said.

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"That vision includes our characteristic humour, traditions, vitality and thoughtfulness as expressed by the cohort of invited artists."

Other regional artists John Murray, Lewis Burns, Gill Pedrana, Pietro Dudek and Locky Naef will be involved with the work.

Art Club Dub is also holding short workshops at the mural for youths.

Macquarie Home Stay director Rod Crowfoot said he was very excited to see the project start.

"There have been some terrific examples of public murals in recent years and we welcome the opportunity to offer this new addition to Dubbo," he said.

"We were keen to include representation from the region which the installation will do and Jack has also been able to include local young people in the art project, enabling them to experience unique and new techniques."

Mr Crowfoot said it would add to the vibrancy and diversity of Dubbo.

"The new fixed wall panels have provided us with a noise barrier, security and privacy for future stages of our patient accommodation facility," he said.

"As the boundary fence along the Golden Highway was very long, we wanted to break the monotony of the fencing profile and add a feature of interest for locals and tourists."

The NSW government's Community Building Partnership Program allowed the fence around Macquarie Home Stay to be completed