Dubbo Hospital's old operating theatres and dialysis unit will soon be knocked down to create a construction zone for the $35 million Western Cancer Centre.
Health infrastructure advised on Friday of the looming demolition works required before the first sod could be turned on the project.
"Early works continues on the site with demolition of the existing buildings to begin in the coming weeks," its spokeswoman told the Daily Liberal.
NSW Health Minister Brad Hazzard announced Lipman Pty Ltd had won the tender for the construction of the two-storey cancer centre during his visit to the hospital in November.
On the ground floor will be a radiation/oncology reception area, radiation therapy bunker and PET CT scanner.
On the second floor will be a reception area and clinic rooms, chemotherapy and haematology treatment spaces, offices and a wellness space for patients and family members.
The cancer centre is expected to be completed early next year.
"The NSW government is delivering the new $35 million Western Cancer Centre which includes a federal government contribution of $25 million," the spokeswoman said.
It will be connected to the under-construction and three-storey Macquarie Building which is set to get bigger when the hospital's existing emergency department and medical imaging unit move into it.
"Part of the new emergency department and the entire medical imaging unit will open in the Macquarie Building in the coming months to enable the building contractor, Hansen Yuncken, to demolish the existing units at the front of the hospital and complete the building in early 2021," the spokeswoman said.
The Macquarie Building will also feature a critical care floor comprising a coronary care/stroke unit, intensive care unit and cardiac catheter laboratory.
It will have an ambulatory care unit, main entry and drop-off zone.
The state government has allocated more than $240 million to four stages of the hospital's redevelopment.