Orana and the Far West has the second-highest employment growth rate in NSW at 15.4 per cent.
Dubbo's 13.8 per cent is higher than Greater Sydney's 13.5 per cent.
The Australian Jobs 2019 report has Regional Development Australia (RDA) Orana pointing to the more than 340 jobs offered in the region in the "past month alone", most of them in the mining and health sectors.
RDA Orana chairman, Dubbo's John Walkom, says business is "booming" in the Orana region with the new report showing a "rapid level of growth" in regional employment.
"At 15.4 per cent, the Orana had the second highest growth in employment in NSW in the past five years," he said.
"Only the Mid North Coast was higher at 16.9 per cent with Greater Sydney (13.5 per cent) behind both Dubbo and Illawarra (13.8 per cent)."
Mr Walkom said the report also revealed 43 per cent of the workforce in Orana had not obtained any post-secondary qualifications.
"Sydney has the most highly-educated workforce in the state, with 71 per cent holding post-school qualifications," he said.
"But as the data shows, this does not equate to employability.
"What is clear is that there are fantastic job and career opportunities in the regions.
"In the past month alone over 340 positions have been advertised in the Orana with majority in the health and mining sectors."
RDA Orana reports of more than four million employees in NSW with "health care and social assistance" the biggest industry employer followed by professional, scientific and technical services.
Employment growth across the state is above the national average, with the largest rises in professional services and construction.
"The level of investment in the Orana region has aided employment growth and is visible across other sectors," Mr Walkom said.
"This has enabled a very healthy economy and strong belief in the future viability and success of the region."
The report was released by the federal government's Department of Jobs and Small Business.