Just before 9.30pm, officers attached to Orana Mid-Western Police District were conducting proactive patrols of the local area, when they observed the driver of a Toyota Aurion acting suspiciously at Cobborah Road.

A pursuit was initiated after the driver allegedly accelerated to speeds of about 100 kilometres/hour in a signposted 50km/h zone.

The pursuit was terminated a short time later due to the manner of driving, after the Toyota allegedly crossed onto the wrong side of the road at Fitzroy Street.

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Officers found the vehicle abandoned at Strickland Crescent and were alerted by residents that a man had been seen running through the backyards of nearby homes.

Following a brief foot pursuit, a 36-year-old man was arrested at the scene.

In a subsequent search of his clothing, officers seized $1460 cash.

Nearly 14 grams of methylamphetamine (ice) was located in a sock nearby and also seized.

Further checks revealed the man's licence had recently been suspended.

He was taken to Dubbo Police Station and charged with police pursuit - not stop - drive dangerously, drive motor vehicle while licence suspended, take part supply prohibited drug (indictable quantity) and knowingly deal with proceeds of crime.

The Trangie man was refused bail and is due to appear at Dubbo Local Court on Saturday.

Following further inquiries, officers attached to Western Region Enforcement Squad (RES) executed a search warrant at a home at Cobborah Road about 1.45am on Saturday.

During the search, officers seized an amount of cocaine and methylamphetamine, as well as prescription medication, more than $2100 cash and mobiles phones.

All items seized will be subject to further examination.

A 33-year-old man was arrested at the home and taken to Dubbo Police Station, where he was charged with owner/occupier knowingly allow use drug premises, three counts of possess prohibited drug, and two counts of deal with property proceeds of crime.

He was also refused bail and is due to appear at Dubbo Local Court on Saturday.