Vaccination will be the "way out" of the COVID-19 pandemic, says Western NSW Local Health District chief executive officer Scott McLachlan.
He wants 80 per cent of residents in the region to be vaccinated against the virus by the end of this year.
The chief executive is looking to establish more vaccination hubs in Dubbo, Orange and Bathurst when the supply of vaccines to the region is boosted.
They include Moderna which Mr McLachlan says will be a welcome addition to the region's "vaccination war chest".
The chief executive announced the region's vaccination goal on the same day the first of two cases of COVID-19 at Dubbo was confirmed.
At a virtual media event on Tuesday afternoon he told of the goal of vaccinating eight out of 10 people in the next four-and-a-half months.
"That's a big challenge for us," Mr McLachlan said.
"We are going to need extra vaccines to make that happen."
The health district's boss also advised of a jump in the number of people in the region getting the jab in the past two weeks.
About 28,000 people had rolled up their sleeves.
"That's a huge volume in Western NSW and a significant increase on the fortnight before that," Mr McLachlan said.
"We know that we are on a trajectory to see all of our towns vaccinated right across the region."
The chief executive said 80 per cent of the vaccinations had been delivered by GPs, pharmacies, Aboriginal medical services and respiratory clinics.
"There is a lot of opportunity for people to get vaccinated right across the region," he said.
The health district's existing and seven-day-a-week vaccination hubs at Dubbo, Orange and Bathurst each currently vaccinate between 2000 and 3000 people a week.
Mr McLachlan told of a "significant increase" in the number of younger people taking up the opportunity to be vaccinated with AstraZeneca.
"I know that the GPs, respiratory clinics, pharmacies and Aboriginal medical services are seeing the same across the region," he said.
"It is a safe and effective, and available vaccination that I really would encourage everyone to look at," he said.
The health district's mobile vaccination clinics will return to small rural communities from next week.
The total number of vaccines administered in NSW was reported on Wednesday morning to be 4,532,296.
NSW Health reports 1,728,339 doses have been administered by its staff to 8pm Tuesday night and 2,863,627 by GPs and other providers to 11.59pm Monday.
For more information on getting vaccinated go to www.health.nsw.gov.au.
Our journalists work hard to provide local, up-to-date news to the community. This is how you can continue to access our trusted content: