That's the message to the Central West after a pet food courier who delivered goods to depots at Parkes and Blayney has since tested positive for COVID-19.

The new case leaked into regional NSW was confirmed at Premier Gladys Berejiklian's press conference on Sunday.

Deputy premier John Barilaro said there's been significant freight movement into areas like Parkes, Molong, Blayney and Orange since the lockdown in Sydney, and with cases now linked to some of those freight lines the leader of the Nationals has pleaded with regional NSW to "stay vigilant in the community".

There were 105 new cases announced at Sunday's press conference in Sydney, 27 of those new cases have been out in the community with infectious.

"It's important we protect regional NSW," Mr Barilaro said.

"My advice to regional NSW is to keep doing what we're doing.

"We have a level of freedom in regional NSW we don't have in Sydney ... and we want to keep that.

"Wear a mask, follow the rules and make sure the message to Sydney is clear: do not come to the regions at this time."

The new COVID-19 scare comes on the back of the confirmed cases that travelled to Orange and Molong on Friday.

The three men have been charged by NSW police after it was established the men, who were working as removalists, had travelled from West Hoxton to Figtree, before travelling to Molong, stopping in regional areas including South Bowenfels and Orange along the way.

It will be alleged three of the men travelled to Molong after being notified they had tested positive to COVID-19.

State Emergency Operations Controller, Deputy Commissioner Gary Worboys said that sort of behaviour was "particularly disturbing" and stressed the penalties for such blatant flouting of current public health orders could land those offending fines of up to $11,000 and jail time.

"Despite the health advice they've left home and put people in regional NSW at risk," Mr Worboys said.

"There's a strong sense that country people won't tolerate this type of behaviour. It puts them at risk."