Leanne Rachel Stewart, 57, will remain in custody after she was refused bail in Dubbo Local Court on Wednesday.

Stewart was arrested and charged after police executed a search warrant at a home on Reid Street in Wellington, about 9.20am on Tuesday morning.

During the search police seized electronic items, cannabis seed, drug paraphernalia and a substance believed to be methylamphetamine, also known as ice.

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Officers also seized power tools suspected of being stolen, with all items to undergo forensic examination.

Stewart was arrested at the home and taken to Wellington Police Station, where she was charged.

The 53 charges included 20 counts of supply prohibited drug, with 17 more counts of that in small quantity, 10 more of indictable quantity and one of commercial quantity.

She was also charged with five counts of supply prohibited drugs on an ongoing basis and owner/occupier knowingly allow use as drug premises.

When applying for bail in court on Wednesday, defence lawyer Carmen Just said Stewart's mental health had been "deteriorating" recently due to grief from the loss of a number of family members and friends.

She said Stewart admitted she had substance abuse issues, and was willing to re-engage with drug and alcohol counselling, which Ms Just argued would be better served in the community.

Ms Just said ultimately due to COVID-19 and expected court delays, Stewart could be in custody for a number of months.

However, Magistrate Gary Wilson refused bail, and the matter will return to Dubbo Local Court on September 9.