Three patients have been bitten by mice in Orana region health facilities as the challenge posed by the plague expands.
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NSW Health confirmed on Thursday there had been three reports of "residents or patients receiving minor bites" from Tottenham, Walgett, and Gulargambone.
Appropriate treatment had been provided, a NSW Health spokesperson said.
Farms and homes have already been battling soaring numbers of the rodents for months, and CSIRO researcher Steve Henry this week said it had become a "full-blown" plague from Armatree northwards.
NSW Health reported of its measures to deal with the vermin.
"The current mouse infestation across western NSW is a natural occurrence," the spokesperson said.
"NSW Health staff are responding with appropriate control measures.
"These include increased baiting and trapping, deterrent measures such as odour repellents and increased frequency of food waste removal, and blocking access by improving seals around doors and windows, yard and grass clearing around buildings, and blocking brickwork weep-holes and other cavities."
In Western NSW Local Health District (WNSWLHD), there have been no cases of leptospirosis, a reportable infectious disease, NSW Health statistics show.
While there have been a total of six cases in other health districts across the state this year, WNSWLHD has not had a reported case since 2017.
WNSWLHD public health manager Priscilla Stanley urged vigilance.
"While the district hasn't had any cases of leptospirosis, it's important for people who work closely with animals, such as farmers, vets and abattoir workers to be aware of the symptoms while we are experiencing an escalation in mouse and rat numbers."
Barwon MP Roy Butler cited the reports of mice in hospitals as he called for the NSW government to acknowledge the "mouse plague" and its impacts on towns, agriculture, businesses and people's well-being.
"Some of our hospitals have patients in hospital getting nibbled on at night, people in their bed being woken up with mice running across their body or through their sheets, in their hair," he said.
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