Constituents have reported of mice biting them in their beds at night, reports Barwon MP Roy Butler who is calling for urgent efforts to control the rodent problem.
The Shooters, Fishers and Farmers Party member says there is a "mouse plague" affecting parts of his electorate and only spreading further.
Reports of mice being on the march first emerged late last year, being seen in both country and urban areas.
Mr Butler said he had raised the issue with NSW Minister for Agriculture Adam Marshall.
He said Mr Marshall had advised him the NSW government had written to the federal government requesting permission from the Australian Pesticides and Veterinary Medicine Authority to allow farmers and councils to use restricted poisons to control mouse numbers.
Mr Butler said that was not looking likely.
"The poisons we used 40 years ago are no longer approved due to collateral kills," he said.
The Barwon MP said he had also written to federal Member for Parkes Mark Coulton, who had replied saying he had appealed to federal agricultural minister David Littleproud.
Mr Butler wants governments to "push the bureaucrats" to act faster on making a decision about the way forward.
"We can't sit around and wait for a cold snap to fix this problem, the mice are already damaging crops in some parts of the state and we do not want to see damage to the post-drought recovery," he said.
"Our communities are being overrun with mice, which is having a hugely negative effect on people's well-being.
Our communities are being overrun with mice, which is having a hugely negative effect on people's well-being.Barwon MP Roy Butler
"I'm being told by people that they are being bitten by mice in their own beds of a night - which is affecting their mental health."
Mr Butler has suggested the NSW government subsidise the cost of baits.
"I know people are doing their best to get on top of the mice in their own homes laying baits and traps but there is fast becoming a shortage of these products in some communities," he said.
"I'm also being contacted by people that simply can not afford to spend a couple of hundred dollars on baits to get on top of the mice in their own home."
Last month Warren farmer Jack Brennan dug up six holes of stubble fallow across a hectare and in every hole he found an average of nine infant mice - posting his findings to Twitter.
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