For Leicester manager Brendan Rodgers, it's a chance to extend his side's one-point lead with a win against his former club, while Liverpool will test their squad strength and flexibility.

Second-placed Tottenham take on Manchester City while fourth-placed Southampton are away to Wolverhampton Wanderers.

Despite a growing injury list, Liverpool are one point off the top and a win over Leicester could see them back on top come the end of the weekend.

To do that, though, they will need to dig even deeper after Joe Gomez became the latest defender to be injured, this time on international duty.

Like Virgil van Dijk, who is recovering from knee surgery, Gomez looks set to miss much of the season, while full back Trent Alexander-Arnold is also out of the Leicester game.

Central defender Joel Matip is fit again but with Fabinho and Jordan Henderson likely to miss out through injury, and Mohamed Salah self-isolating with the coronavirus, manager Juergen Klopp will have to use his full squad.

Wilfried Ndidi will be missing in the Leicester midfield but goalkeeper Kasper Schmeichel looks set to start after recovering from a blow to his head while playing for Denmark in midweek.

With Liverpool and Leicester meeting on Sunday evening, Tottenham could hit the top for 24 hours at least, if they can beat Manchester City on Saturday.

Spurs manager Jose Mourinho will hope to have Son Heung Min available after he flew home early from international duty when five South Korea players tested positive for the virus.

Mourinho could give Gareth Bale a start after the midfielder played an hour for Wales in their win over Finland.

The 31-year-old has been eased in by Mourinho since his return from Madrid but is closing in on a starting spot.

"The more games I'm playing the better the body is adapting," Bale said in midweek. "I still need to get a little fitter and sharper but I am getting there.

"It takes a bit of time when you're a bit older, but I am just excited to get back to full fitness and hopefully it won't be too long."

City may look to Ferran Torres for goals after the Spaniard scored a hat-trick in the 6-0 win over Germany in midweek, though Sergio Aguero could return from injury.

Fifth-placed Chelsea, three points behind leaders Leicester, travel to Newcastle in the lunchtime kickoff on Saturday.

Aston Villa welcome Brighton & Hove Albion, with midfielder Jack Grealish in form after starring in two England matches.

Manchester United, sitting in 14th with just 10 points from seven games, face West Bromwich Albion.

Bottom side Sheffield United host West Ham, second-bottom Burnley meet Crystal Palace on Monday while Leeds take on Arsenal.

Australian Associated Press