Police were called to deal with a house party at Moree twice, and on the second time while dispersing about 100 people they were allegedly assaulted and had glass bottles thrown at them and their vehicles, NSW Police said in a statement.

An officer sustained injuries while performing duties, and the strife consumed police resources for a number of hours overnight, police said.

Just before 11.15pm on Saturday officers attached to New England Police District attended a home on Adelaide Street at Moree after receiving noise complaints about a house party, NSW Police said in a statement.

On arrival, police spoke to the owner of the home and issued a noise abatement direction.

A short time later, police were called back to the Adelaide Street address about 12.30am on Sunday after reports of multiple brawls between party guests.

Police attended and began to disperse a crowd of about 100 people in the front yard, when they were allegedly assaulted and had glass bottles thrown at them and their vehicles.

Capsicum spray was deployed, and four people - two men aged 22 and 26 and two women aged 38 and 35 - were arrested and taken to Moree Police Station.

Following inquiries, the 22-year-old man was charged with refuse/fail to comply with direction, affray, assault police officer in execution of duty cause actual bodily harm, three counts of assault officer in execution of duty, resist officer in execution of duty, intimidate police officer in execution of duty, possess prohibited drug, and possess car breaking implements.

The 26-year-old man was charged with assault officer in execution of duty, resist officer in execution of duty, and affray.

They were both refused bail to appear before Moree Local Court on Sunday.

The 35-year-old woman was charged with affray and violent disorder.

She was granted conditional bail to appear before Moree Local Court on August 28.

The 38-year-old woman was released pending further inquiries.

About 2.20am, police were conducting additional patrols of the street when they observed a fight between two men.

The pair - aged 29 and 23 - were arrested and taken to Moree Police Station.

Police have been told the older man allegedly drove his car towards the younger man, coming to a stop in front of him.

The man exited the vehicle and a physical altercation is alleged to have taken place.

The men are known to each other.

The two men were charged with domestic violence related common assault and the older man was additional charged with drive recklessly/furiously or speed/manner dangerous.

They were granted conditional bail to appear before Moree Local Court on August 28.

A male constable sustained facial bruising during the incident and the police vehicles sustained minor damage.

Inquiries continue.