At about 6am, 10 search warrants were simultaneously issued in Wellington and Montefiores, in addition to another five associated warrants in Sydney.

Ten people were arrested, including seven men - a 44-year-old, a 34-year-old, 28-year-old, 29-year-old, 30-year-old, and two 37-year-olds - and three women - a 28-year-old, 23-year-old and 35-year-old.

Six men were also arrested in Sydney.

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"We will allege this operation has resulted in the complete dismantling and smashing of a significant methamphetamine, MDMA and other drug syndicate in the Wellington sector," Acting Assistant Commissioner McKenna said.

It's estimated $10 million worth of drugs were taken off the streets.

He said the syndicate had far-reaching tentacles into the Central West, including in Bourke, Walgett, Cobar and some correctional centres.

"We've taken out drug runners, street level suppliers, medium level suppliers and 'kingpins' in Sydney," Acting Assistant Commissioner McKenna said.

As well as thanking all of the officers involved, Acting Assistant Commissioner McKenna said he was grateful to the Wellington residents.

"The Wellington community, I'd like to think, will be joining us in celebrating what was a terrific result today in taking people who want to pedal these insidious drugs off the streets and into jail where they belong."

The arrests on Wednesday were the results of a 14 month investigation.

Assistant Commissioner McKenna reassured the public that the police do listen.

"A lot of the time they might think 'what are the police doing?' but we can't come out and tell you what we're doing. We have to work behind-the-scenes, we have to work covertly so we can get the true criminality of these people and put them before the courts," he said.

Further arrests are expected to be made.

Anyone with information is encouraged to call Dubbo Police on 6883 1599 or Crime Stoppers on 1800 333 000.

The arrests made on Wednesday over an alleged drug syndicate are "critically important" to Wellington, says Dubbo MP Dugald Saunders.

"[Assistant Deputy Commissioner Peter McKenna], along with a number of other local police have been with me at meetings in Wellington with business owners who have been affected by crime and there has been a genuine concern around a small number of people creating a lot of mischief at Wellington," Mr Saunders said.

"To be able to actually hit them hard, put that line in the sand and know that we've actually smashed a large collaboration that's been going on for some time is critically important."

The Dubbo MP said this was the beginning of showing the criminals there days were numbered if they continued to be involved in illegal drug activity.

While Wellington has a bad reputation for the illegal drug ice, Mr Saunders said it was not deserved.

"Wellington sadly, and I think part of it has been a media beat up for many years, is associated with ice. But there's no more ice at Wellington than there is in Orange or Dubbo or any of our larger cities, it's just that it's got that name so it's stuck," he said.

"We know that Wellington residents have been genuinely affected by a small number of people who keep committing crimes. Much of their crime is related to drugs, drug use, drug supply and I'm hoping this is the start of the end."

Mr Saunders said the NSW government was still looking at a drug and alcohol rehabilitation facility, however COVID-19 had temporarily put the plans on hold.

"Rest assured, all that is being looked at and it won't just be one solution, there'll be a mix of solutions that will help solve this in the future."